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Emergence and phenotypic characterization of C.1.2, a globally detected lineage that rapidly accumulated mutations of concern

Authors :
James Emmanuel San
Koleka Mlisana
Vicky L Baillie
Richard J Lessells
Tulio de Oliveira
Thabo Mohale
Zamantungwa T. H. Khumalo
Carolyn Williamson
Noxolo Ntuli
Prudence Kgagudi
Wolfgang Preiser
Wesley C. Van Voorhis
Josie Everatt
Shabir A. Madhi
Anele Mnguni
Florette K. Treurnicht
Cathrine Scheepers
Bronwen E. Lambson
Sureshnee Pillay
Nicole Wolter
Linda-Gail Bekker
Nelia P. Manamela
Penny L. Moore
Yeshnee Naidoo
Zinhle Makatini
Daniel G. Amoako
Nokukhanya Msomi
Jennifer Giandhari
Anne von Gottberg
Sandile Cele
Alex Sigal
Marietje Venter
Arshad Ismail
Houriiyah Tegally
Nei-yuan Hsiao
Eduan Wilkinson
Constantinos Kurt Wibmer
Tongai Maponga
Glenda Gray
Jinal N. Bhiman
Boitshoko Mahlangu
Gaurav Kwatra
Simone I. Richardson
Darren P. Martin
Upasana Ramphal
Publication Year :
2021
Publisher :
Cold Spring Harbor Laboratory, 2021.

Abstract

Global genomic surveillance of SARS-CoV-2 has identified variants associated with increased transmissibility, neutralization resistance and disease severity. Here we report the emergence of the PANGO lineage C.1.2, detected at low prevalence in South Africa and eleven other countries. The emergence of C.1.2, associated with a high substitution rate, includes changes within the spike protein that have been associated with increased transmissibility or reduced neutralization sensitivity in SARS-CoV-2 VOC/VOIs. Like Beta and Delta, C.1.2 shows significantly reduced neutralization sensitivity to plasma from vaccinees and individuals infected with the ancestral D614G virus. In contrast, convalescent donors infected with either Beta or Delta showed high plasma neutralization against C.1.2. These functional data suggest that vaccine efficacy against C.1.2 will be equivalent to Beta and Delta, and that prior infection with either Beta or Delta will likely offer protection against C.1.2.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........41c2cf2cdcbd0fb42f5b3d2984f8352d
Full Text :
https://doi.org/10.1101/2021.08.20.21262342