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Clinical Features and Outcomes of Posterior Reversible Encephalopathy Syndrome in Patients With Systemic Lupus Erythematosus
- Source :
- Arthritis Care & Research. 65:1766-1774
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Objective To analyze the clinical features and outcomes of patients with posterior reversible encephalopathy syndrome (PRES), the risk factors of PRES-related intracranial hemorrhage (ICH), and all-cause mortality in patients with systemic lupus erythematosus (SLE). Methods Twenty-six episodes of PRES were identified in 23 SLE patients, using an electronic medical records database of 3,746 SLE patients. Results The prevalence of PRES was 0.69% among SLE patients. The scores of the SLE Disease Activity Index without neurologic descriptors (SLEDAI-N) were significantly elevated from baseline for a mean of 3.3 during PRES (P = 0.009). Rapidly deteriorating renal function, pulmonary hemorrhage, thrombotic microangiopathy, macrophage activation syndrome, or multiple organ dysfunction syndrome appeared during 65.4% of episodes. In 16 episodes, patients completely recovered from PRES-related symptoms within a median of 7 days. Visual impairment was reversed within 2 days in 8 of 15 patients, but impairment in other patients was protracted for up to 4 months, especially when ICH was present. Hypoalbuminemia ( 18 during a PRES attack had significantly higher mortality rates than did patients with SLEDAI-N scores ≤18 (P = 0.009 by log rank test). Conclusion PRES frequently occurs during active SLE with multiple complications. Hypoalbuminemia and thrombocytopenia may contribute to PRES-related ICH. The extraneurologic disease activity of lupus during PRES may influence the mortality rate of SLE patients.
- Subjects :
- medicine.medical_specialty
Thrombotic microangiopathy
Systemic lupus erythematosus
Lupus erythematosus
business.industry
Posterior reversible encephalopathy syndrome
medicine.disease
Gastroenterology
Rheumatology
Internal medicine
Macrophage activation syndrome
Immunology
medicine
Hypoalbuminemia
Pulmonary hemorrhage
skin and connective tissue diseases
Multiple organ dysfunction syndrome
business
Subjects
Details
- ISSN :
- 2151464X
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Arthritis Care & Research
- Accession number :
- edsair.doi...........41a53dec73af26b39053638c7386f645