A comparison of the effect of lofepramine, maprotiline and placebo on information processing in healthy volunteers

Single oral doses of lofepramine (140 mg), maprotiline (100 mg), and placebo were administered in a randomized three-way crossover design with 1 week wash-out between administrations to 12 healthy male volunteers. Before, and 1, and 3 h post-administration a battery of performance tests was administered which included a digit-matching paradigm and a reaction test separating recognition and motor time. In contrast to maprotiline, lofepramine did not impair speed and accuracy of cognitive performance.