Design and In-Vitro Evaluation of Nicorindil Biphasic Drug Delivery System for Angina Pectoris

Biphasic tablet system made of immediate and sustained release tablet core was prepared by direct compression. The outer layer was formulated to release of drug in very short time, while the mini-tablets provided a sustained passion of drug release. Immediate release component comprised of croscarmellose sodium (5%), while mini-tablet was formulated using different concentration of Olibanum gum. The in vitro drug release profile from these tablets showed desired biphasic release behavior. The Nicorandil contained in immediate release component was dissolved within 2 min, whereas drug in mini-tablets was released at different times, depending on the composition of mini-tablets. Dissolution profile was studied in the medium 0.1 N HCl for first 1 h, then Phosphate Buffer Saline pH 6.8 for remaining period of time. TSP and Olibanum gum core was suitable for providing drug release over 7 h time period.