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SND1 expression in breast cancer tumors is associated with poor prognosis
- Source :
- Annals of the New York Academy of Sciences. 1433:53-60
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Staphylococcal nuclease domain-containing 1 (SND1) expression is crucial for breast cancer metastasis; however, the clinical implications of SND1 expression in breast cancer remain unclear. This study investigated the relationship of SND1 protein expression both with metastasis and the prognoses of 144 breast cancer patients over a 10-year follow-up. Chi-square tests revealed that the percentages of positive SND1 expression in breast cancer tumors were significantly associated with larger tumor size (>2 cm, P = 0.043), higher clinical TNM stage (P = 0.003), and positive lymph node metastasis (P = 0.001). Breast cancer patients with positive SND1 expression had a significantly shorter overall survival and disease-free survival than those with negative SND1 expression (P < 0.01). Multiple Cox regression analysis indicated that SND1 expression is an independent risk factor for shorter disease-free survival (hazard ratio = 1.97, P = 0.014). The percentages of SND1 expression in metastatic breast cancers were significantly higher than that in primary tumors in 30 patients with advanced breast cancer (P = 0.016). Therefore, SND1 protein expression is significantly associated with breast cancer metastasis and may serve as a biomarker for prognosis of breast cancer patients.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Proportional hazards model
business.industry
General Neuroscience
Hazard ratio
Cancer
medicine.disease
General Biochemistry, Genetics and Molecular Biology
Metastasis
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Breast cancer
History and Philosophy of Science
030220 oncology & carcinogenesis
Internal medicine
Medicine
Biomarker (medicine)
Stage (cooking)
Risk factor
skin and connective tissue diseases
business
Subjects
Details
- ISSN :
- 00778923
- Volume :
- 1433
- Database :
- OpenAIRE
- Journal :
- Annals of the New York Academy of Sciences
- Accession number :
- edsair.doi...........4146eef0695fbd578fd23aeb7fbaa56c