Synthesis of enantiomerically pure 9[(1′R,2′R,3′S)-bis(hydroxymethyl)thietan-1′-yl]adenine, 3′-thio analog of oxetanocin A

The enantiomerically pure synthesis of 9-[(1′ R ,2′ R ,3′ S )-bis(hydroxymethyl)thietan-1′-yl]adenine 2 , 3′-thio analog of oxetanocin A, was achieved via coupling with sulfoxide 17 and 6-chloropurine in the presence of TMSOTf and Et 3 N under the Pummerer reaction conditions.