A benzimidazolium-based new flexible cleft built on the piperazine unit: a case of selective fluorometric sensing of ATP

Authors :: Asmita Samadder
Debojyoti Tarafdar
Kumaresh Ghosh
Anisur Rahman Khuda-Bukhsh
Source :: RSC Adv.. 4:58530-58535
Publication Year :: 2014
Publisher :: Royal Society of Chemistry (RSC), 2014.
Abstract: A benzimidazole-based compound 1 built on the piperazine motif has been designed and synthesized. The chemosensor 1 is highly selective and sensitive towards ATP over ADP and AMP in CH3CN/H2O (1 : 1, v/v, using 10 mM HEPES buffer, pH 6.4) as evidenced by the significant change in emission. Furthermore, sensor 1 is cell permeable and can detect the presence of ATP in Human cervical cancer cells (HeLa).

Subjects :: Benzimidazole
biology
Chemistry
Stereochemistry
General Chemical Engineering
Cell
General Chemistry
Highly selective
biology.organism_classification
Hepes buffer
HeLa
chemistry.chemical_compound
Piperazine
medicine.anatomical_structure
Cervical carcinoma
medicine

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