Safety and efficacy of buparlisib (BKM120) and chemotherapy in advanced, squamous non-small cell lung cancer (sqNSCLC): Results from the phase Ib/II BASALT-2 and BASALT-3 studies

Authors :: Jaafar Bennouna
Enriqueta Felip
Diego Cortinovis
Arunava Chakravartty
Juergen Alt
Eric Scott Schaefer
Marie Chol
Alessandro Morabito
Alex A. Adjei
Francesco Grossi
Paola Aimone
Luis Paz-Ares
David Planchard
Joan Maier
Javier de Castro
Tommaso De Pas
Natasha B. Leighl
Christos Chouaid
Michael Thomas
Source :: Journal of Clinical Oncology. 34:e20522-e20522
Publication Year :: 2016
Publisher :: American Society of Clinical Oncology (ASCO), 2016.
Abstract: e20522Background: Phosphatidylinositol 3-kinase (PI3K) pathway activation may contribute to primary and secondary resistance to platinum (Pt)-based chemotherapy (CT) in sqNSCLC. The pan-PI3K inhibi...

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