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Gadolinium(III) chelated conjugated polymer as a potential MRI contrast agent
- Source :
- Polymer. 51:1336-1340
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Nuclear magnetic resonance imaging (MRI) has become a powerful technique in clinical diagnostics. In this work, a new MRI contrast agent by covalently linking Gd(III) chelates to the side chain of conjugated polymer (PF–Gd) is synthesized by Suzuki cross-coupling reaction. The PF–Gd exhibits a higher relaxivity and a pronounced enhancement in contrast than that of (NMG) 2 –Gd–DTPA widely used for clinical diagnosis. This work should be feasible to potentially lead to a new class of imaging contrast agents.
Details
- ISSN :
- 00323861
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Polymer
- Accession number :
- edsair.doi...........411b0483a0b02d230b400547c17272bf