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Management of Proximal Primary Urethral Cancer
- Source :
- Urologic Clinics of North America. 43:505-513
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Primary urethral cancer (PUC) is a rare, but devastating genitourinary tumor that affects men and women. Although most PUC are localized, proximal PUC frequently presents with locally advanced disease, with 30% to 40% having lymph node metastasis. Single modality surgical or radiation therapy has dismal results. Multimodal therapy with cisplatin-based chemotherapy and consolidation surgery has greatly improved the local recurrence and overall survival rates for this aggressive disease. In locally advanced squamous cell carcinoma of the urethra, radiotherapy combined with radiosensitizing chemotherapy is an option for genital preservation. Prospective, multi-institutional studies are required to further define the optimal multidisciplinary treatment strategy for this destructive disease.
- Subjects :
- medicine.medical_specialty
Chemotherapy
Urethral Carcinoma
business.industry
Genitourinary system
Urology
medicine.medical_treatment
030232 urology & nephrology
Multimodal therapy
Disease
medicine.disease
Surgery
Radiation therapy
03 medical and health sciences
0302 clinical medicine
Urethra
medicine.anatomical_structure
030220 oncology & carcinogenesis
medicine
business
Urethral cancer
Subjects
Details
- ISSN :
- 00940143
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Urologic Clinics of North America
- Accession number :
- edsair.doi...........40ee067b1a25abba84166460de6f9ec4