414: Risk factors of neurological damage in infants with asphyxia

in infants with asphyxia Cristina Plevani, Ilaria Pozzi, Anna Locatelli, Silvia Malguzzi, Gaia Kullmann, Maddalena Incerti, Giuseppe Paterlini MBBM Foundation, University of Milano-Bicocca, Obstetrics and Gynecology, Monza, Italy, MBBM Foundation, San Gerardo Hospital, Neonatology, Monza, Italy OBJECTIVE: Hypoxic-ischemic encephalopathy (HIE) occurs in the first days of life in asphyxiated term neonates. Our objective is to identify markers predictive of moderate-severe HIE and long term adverse neurodevelopmental outcome (ANDO) among neonates with asphyxia. STUDY DESIGN: All term asphyxiated neonates (umbilical artery (UA) pH 7.0 or base excess (BE) -16 or Apgar 5 at 5 min or need of intubation or prolonged resuscitation at birth) inborn between January 2004 and June 2011 were prospectively admitted to a clinical and instrumental monitoring protocol and at least 12 months follow-up. Data on antenatal, intrapartum risk factors, placental histology and neonatal outcome were collected. HIE was defined as mild, moderate and severe according to modified SarnatSOR 145) and UA BE (p 0.04; OR 0.7) were independently related to moderate-severe HIE and ANDO. CONCLUSION: Among neonates with asphyxia, the risk of developing moderate-severe HIE or ANDO is predicted by perinatal factors, i.e. need for intubation and UA BE. Neither antenatal and intrapartum risk factors nor placental histology are helpful to identify these outcomes.