Integrative Therapiemöglichkeiten des inoperablen Pankreaskarzinoms – eine Übersicht

In the treatment of adenocarcinoma of pancreas adjuvante and palliative treatment is of great importance. However the sucess of evidence based standard therapies in pancreatic carcinoma with Gemcitabine-monotherapy or other polychemotherapies are very limited, thus alternatives and innovative treatment options are required. This paper provides an overview of new strategies in surgical treatment and palliative local cytostatic and immunologic therapy options. The results of own studies using integrative approaches with mistletoe concomitant to chemotherapy are promising. Mistletoe therapy exerts positive effects on quality of life, chemotherapy related adverse effects and symptoms due to illness are reduced, time of hospitalization is shortened. Besides subcutaneous application of mistletoe intratumoral application is very effective. An own pilot study in hospital Havelhoehe in Berlin, Germany with 14 patients showed a local response in 92 % of patients concerning tumor reduction, prolongation of survival time and improvement of quality of life. Further complementary therapy options concomitant to chemotherapy like administration of antioxidants, vitamin C and E, selenium and glutathione are presented.