AB0553 STUDY OF ANXIETY AND DEPRESSION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

Objectives: To study the prevalence of anxiety and depression in a cohort of patients with SLE at King’s College Hospital in London,as well as its relationship with characteristics of disease and treatments Methods: Cross-sectional study of a cohort of patients with SLE.All patients with SLE who had been included in the IMPARTs project(Integrating Mental and Physical healthcare:Research,Training and Services)were recruited between 2012-2016.All patients filled out the following questionnaires on a tablet device:PHQ9(Patient Health Questionnaire)(Scores of 10 or more have an sensitivity and specifity close to 90% for major depression) and GAD-7(7-item Generalized Anxiety Disorder)(Scores of 10 or more have an sensitivity and specifity close to 89% and 82% for GAD).Variables:demographic, duration of the disease(months)and the profile of autoantibodies.Previous history of depression or anxiety. SLEDAI,treatments,ESR, CPR,C3 and C4.Statistical analysis:descriptive, bivariate using T-Student and χ2. Results: A total of 129 patients with SLE were included. Clinical characteristics in Table 1. 38 patients (29.5%)had some degree of major depression and 27(20.9%)generalized anxiety disorder(Table 2).The prevalence of major depression was higher in patients with anti RO52(42.3%vs23.8%, p=0.06),with generalized anxiety (81.5%vs 15.7%,p Conclusion: The prevalence of anxiety and depression in our group of patients was high,both related, as well as with the perception of pain and fatigue.A correct assessment of these manifestations and early treatment could help improve the quality of life of patients Disclosure of Interests: None declared