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TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus
- Source :
- Arthritis & Rheumatism. 43:129-134
- Publication Year :
- 2000
- Publisher :
- Wiley, 2000.
-
Abstract
- Objective To evaluate the respective contributions of tumor necrosis factor (TNF) promoter polymorphisms and HLA–DR alleles to susceptibility to systemic lupus erythematosus (SLE). Methods TNF-238G/A and 308G/A promoter polymorphisms and HLA–DRB1 alleles were determined in 99 consecutive Caucasian SLE patients and 177 Caucasian controls. Standard and Mantel-Haenszel odds ratios were calculated to assess the magnitude of the susceptibility factors. The presence or absence of the SLE classification criteria was determined and correlated with the TNF promoter and HLA–DRB1 genotypes. Results The frequency of the TNF-308A/A and 308G/A genotypes was significantly higher in SLE patients (odds ratio 5.0). Conversely, TNF-238G/A and 238A/A genotypes were equally prevalent in SLE patients and controls. The HLA–DR3 specificity (DRB1*0301 allele) was significantly more prevalent in the SLE population (odds ratio 4.4). Stratification to correct for interdependence of the 2 loci confirmed the association of both TNF-308A and HLA–DR3 with SLE (Mantel-Haenszel odds ratio 3.2 and 2.4, respectively). No correlation was found between TNF promoter and HLA–DRB1 genotypes and any SLE classification criterion or disease manifestation. Conclusion TNF-308A and HLA–DR3 alleles are independent susceptibility factors for SLE.
- Subjects :
- education.field_of_study
Systemic disease
Lupus erythematosus
Immunology
Population
HLA-DR3
Odds ratio
Biology
medicine.disease
Connective tissue disease
Rheumatology
immune system diseases
Genotype
medicine
Immunology and Allergy
Pharmacology (medical)
Allele
skin and connective tissue diseases
education
Subjects
Details
- ISSN :
- 15290131 and 00043591
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Arthritis & Rheumatism
- Accession number :
- edsair.doi...........400aef4fad27e39b575ee8506e83a378