A lignan from Schizandra chinensis

A new dibenzocyclooctadiene lignan, isoschizandrin was isolated from the fruits of Schizandra chinensis . The structure was elucidated on the basis of the spectral analysis and chemical correlation with schizandrin and (+)− deoxyschizandrin. In experiments using rats, schizandrin and its derivatives, including isoschizandrin, showed inhibitory effects on stress-induced gastric ulceration (p.o.).