Synthesis and cyclooxygenase and 5-lipoxygenase inhibitory activity of some thiazolidene-4-one analogs of meclofenamic acid

Authors :: Clifford D. Wright
Paul J. Kuipers
David T. Connor
Diane H. Boschelli
Source :: Bioorganic & Medicinal Chemistry Letters. 2:705-708
Publication Year :: 1992
Publisher :: Elsevier BV, 1992.
Abstract: Replacement of the carboxylic acid functionality of meclofenamic acid with select heterocycles converted this cyclooxygenase (CO) inhibitor into dual inhibitors of CO and 5-lipoxygenase (5-LO).

Subjects :: chemistry.chemical_classification
biology
Chemistry
Stereochemistry
Carboxylic acid
Organic Chemistry
Clinical Biochemistry
Pharmaceutical Science
Inhibitory postsynaptic potential
Biochemistry
Meclofenamic acid
Drug Discovery
Arachidonate 5-lipoxygenase
biology.protein
medicine
Molecular Medicine
Cyclooxygenase
Molecular Biology
medicine.drug

Full Text Access

Tools