OBTENTION OF HISTOCOMPATIBLE STRAINS IN THE URODELE AMPHIBIAN PLEURODELES WALTLII MICHAH. (SALAMANDRIDAE)

SUMMARY Histocompatibility antigens have been studied by skin grafting in three successive generations of the Urodele Pleurodeles waltlii Michah. Starting from a brother-sister pair of animals (F1) mutually tolerant, the descendence obtained in F2 is composed of three types of animals called A/A, A/B, B/B according to their mutual capacity for tolerance or rejection. The three types are numerically divided according to the mendelian proportions of monohybridism, that is 25 % of A/A, 50% of A/B and 25% of B/B. All the descendants (F3) born of homozygote parents A/A or B/B are homozygote. The descendants (F3) born of heterozygote parents A/B are composed of type A/A, A/B and B/B animals in mendelian proportions of mono-hybridism. The presence of histocompatibility antigens A and B would be determined by a pair of dominant alleles which are on a locus carried by the same pair of chromosomes.