Micro Analysis System with an Integrated Microfluidic System Based on Electrowetting

Electrowetting was used to fabricate an integrated highly efficient microfluidic transport system. As an option, a row of elongated gold working electrodes were used to generate a driving force to mobilize a solution in a flow channel. Flow velocity could be changed by changing the potential of the working electrode. The solutions could be transported to any desired direction without using any valves. In another option, a working electrode was formed in a hydrophilic flow channel and used as a valve. When the valve was switched on, a solution in the flow channel passed the area and went forward by capillary action. Furthermore, two solutions transported through two flow channels could be mixed based on the same principle. Integrated biosensing systems could easily be constructed using these microfluidic components. In this study, the concentration of L-amino acids was determined by generating electrochemical luminescence (ECL) on an integrated platinum working electrode. Also, the activity of protease could be determined using an integrated potentiometric pH-sensing system