Back to Search
Start Over
N-acylhydrazones containing thiophene nucleus: a new anticancer class
- Source :
- Medicinal Chemistry Research. 26:1605-1608
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- In this study, we present a series of N-acylhydrazones containing thiophene nuclei as a new anticancer class. Fifty-seven compounds in this series were evaluated for their activity against four human cancer cell lines. Cytotoxicity (IC50) ranged from 0.82 to 12.90 μM. The compound (E)-N′-(2-hydroxy-3-methoxybenzylidene)thiophene-2-carbohydrazide displayed good cytotoxic activity in all cell lines (IC50 = 0.82–5.36 μM) and yielded the best result in this series; therefore, it is an important lead compound in this new class.
- Subjects :
- 010405 organic chemistry
Stereochemistry
Organic Chemistry
010402 general chemistry
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
chemistry.chemical_compound
medicine.anatomical_structure
chemistry
Cell culture
Thiophene
medicine
Cytotoxic T cell
General Pharmacology, Toxicology and Pharmaceutics
Cytotoxicity
Nucleus
Lead compound
IC50
Human cancer
Subjects
Details
- ISSN :
- 15548120 and 10542523
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Medicinal Chemistry Research
- Accession number :
- edsair.doi...........3f1a512743165b78ef7ae52355411b20