Synthesis of PEG-Modified GoldMag Nanoparticles (PGMN) Loaded Tubeimoside-2 (PGMNT)

PEG-modified GoldMag nanoparticles (PMGN) were synthesized and characterized by TEM and it showed that the size of the composite nanoparticles is range of 50 nm and its saturation magnetization (Ms) was 34 emu/g with zero remanence on the magnetization loop, which was lower than that of GoldMag nanoparticles (42 emu/g). The drug loading rates of PGMN loaded Tubeimoside-2 were 4.11, 11.58 and 11.6 % at the concentration of 0.1, 0.2 and 0.3 mg/ml. The drug loading rates of PGMN marked high than that of GoldMag particles. Our results suggest that PMGN would be developed as a new magnetic targeted drug carrier.