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Biosynthesis of heparan sulfate on beta-D-xylosides depends on aglycone structure
- Source :
- Journal of Biological Chemistry. 269:300-307
- Publication Year :
- 1994
- Publisher :
- Elsevier BV, 1994.
-
Abstract
- We have reported that 3-estradiol-beta-D-xyloside primes heparan sulfate synthesis in Chinese hamster ovary cells and that the proportion of heparan sulfate made rises with increasing concentration of xyloside (Lugemwa, F.N. and Esko, J.D. (1991) J. Biol. Chem. 266, 6674-6677). Using estradiol as a guide, we varied the structure of the aglycone and showed that beta-D-xylosides containing two fused aromatic rings efficiently prime heparan sulfate. Thus, 2-naphthol-beta-D-xyloside primed heparan sulfate at low dose (
Details
- ISSN :
- 00219258
- Volume :
- 269
- Database :
- OpenAIRE
- Journal :
- Journal of Biological Chemistry
- Accession number :
- edsair.doi...........3dfebbbb57d43e0eb6fcccf87379c87e