Back to Search Start Over

Increased Tetanic Fade Produced by 3,4-Diaminopyridine in the Presence of Neuromuscular Blocking Agents

Authors :
Alasdair J. Gibb
W.C. Bowman
Ian G. Marshall
Publication Year :
1982
Publisher :
Elsevier, 1982.

Abstract

Publisher Summary In the presence of tubocurarine, aminopyridine enhances the rundown of trains of endplate potentials. It is possible that this effect may reflect a prejunctional action of tubocurarine, acting to reduce transmitter mobilization. This chapter discusses a study to investigate increased tetanic fade produced by 3,4-diaminopyridine (DAP) in the presence of neuromuscular blocking agents. This study examined the ability of DAP to enhance the fade of tetanic tension (50 Hz for 1.9 s) produced by a range of nondepolarizing neuromuscular blocking agents in the isolated rat phrenic nerve–hemidiaphragm preparation. DAP alone (50 μM) increased twitch and tetanic tension by 256 ± 17% and 21 ± 7%, respectively, and caused only 2.5 ± 0.9% tetanic fade. The concentrations of neuromuscular blockers that produced 26 ± 8.6% tetanic fade under equilibrium conditions were chosen and DAP (50 μM) was added.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........3d96bcac9345ecf781bb072e9c719c18
Full Text :
https://doi.org/10.1016/b978-0-08-028000-4.50030-0