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Increased Tetanic Fade Produced by 3,4-Diaminopyridine in the Presence of Neuromuscular Blocking Agents
- Publication Year :
- 1982
- Publisher :
- Elsevier, 1982.
-
Abstract
- Publisher Summary In the presence of tubocurarine, aminopyridine enhances the rundown of trains of endplate potentials. It is possible that this effect may reflect a prejunctional action of tubocurarine, acting to reduce transmitter mobilization. This chapter discusses a study to investigate increased tetanic fade produced by 3,4-diaminopyridine (DAP) in the presence of neuromuscular blocking agents. This study examined the ability of DAP to enhance the fade of tetanic tension (50 Hz for 1.9 s) produced by a range of nondepolarizing neuromuscular blocking agents in the isolated rat phrenic nerve–hemidiaphragm preparation. DAP alone (50 μM) increased twitch and tetanic tension by 256 ± 17% and 21 ± 7%, respectively, and caused only 2.5 ± 0.9% tetanic fade. The concentrations of neuromuscular blockers that produced 26 ± 8.6% tetanic fade under equilibrium conditions were chosen and DAP (50 μM) was added.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........3d96bcac9345ecf781bb072e9c719c18
- Full Text :
- https://doi.org/10.1016/b978-0-08-028000-4.50030-0