A Facile Approach to α‐Keto Esters via Oxidative Esterification of α‐Amino Carbonyl Compounds

A direct oxidative esterification of alpha-amino carbonyl compounds by two kinds of hydroperoxides, for the synthesis of alpha-keto esters has been developed. The reaction shows broad substrates scope and good functional group tolerance, even for the synthesis of bulkyl esters, and is free of metal catalysts and external additives. Notably, the inhibitor of protein tyrosine phosphatases (PTPases) could be successfully synthesized with our protocol.