Back to Search
Start Over
Evaluation of two methods for quantitation of hepatitis C virus RNA*, **
- Source :
- Molecular Diagnosis. 2:39-46
- Publication Year :
- 1997
- Publisher :
- Elsevier BV, 1997.
-
Abstract
- Background: Accurate quantitation of hepatitis C virus (HCV) RNA in serum may provide a means to predict disease course and response to interferon-alpha therapy. Several quantitative assays are commercially available, but none have been accepted as the gold standard. Methods and Results: The branched DNA quantitative hybridization assay (Quantiplex HCV 1.0, Chiron, Emeryville, CA) and a quantitative reverse transcription polymerase chain reaction (Amplicor HCV MONITOR, Roche Diagnostic Systems, Branchburg, NJ) were compared using a panel of 53 sera from patients with chronic hepatitis C. All sera contained HCV RNA of known genotype. Overall, there was a positive correlation between the results for the 41 sera that gave discrete values in both tests (r =.81, linear regression; P
Details
- ISSN :
- 10848592
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Molecular Diagnosis
- Accession number :
- edsair.doi...........3d1900e5fee55f6a9c462dfa1cbceb69