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Modification of guanine residues in PNA-synthesis by PyBOP
- Source :
- Tetrahedron Letters. 47:5893-5896
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- The phosphonium-type coupling reagent PyBOP, when applied to the synthesis of peptide nucleic acid (PNA) oligomers, was found to form O 4 -phosphonium compounds of the nucleobase guanine which can be converted into C 4 -modified guanine-derived PNAs by nucleophiles.
Details
- ISSN :
- 00404039
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........3ca76bf8a0949f0b2f728478bb498b5a
- Full Text :
- https://doi.org/10.1016/j.tetlet.2006.06.069