Attempts at Improving Maternal, Neonatal Outcome with Megathaimine

Background Various micronutrients are needed in pregnancy for growth of baby, preventionof disorders which affect mother and baby. Thiamineis one such micronutrient. Pregnantwomen have greaterrisk of deficiency. Research continues. Objectives: Study was conducted to know effects of high dose Thiamine ‘Megathiamine’ for prevention of pregnancy specific disorders, better maternal neonatal outcome so as to be able to use knowledge for maternal - neonatal health promotion even with limited resources as Thiamine does not cost much. Material Methods Study subjects were women with 14±2 weeks pregnancy who presented for prenatal care, had no medical, obstetric disorder at inclusion in study, no contraindication to Thiamine. End point was one week beyond birth. Study subjects,1200 women were divided into two Groups A, B. Each arm with 600 women was given Megathiamine or Placebo in triple blinded way. Women who received Megathiamine or Placebo (known only to pharmacologist not part of care providers ) were followed, up to one week post birth till there were 500 births in each arm . Results After completion of study and analysis of results, decoding revealed that anaemia was almost in double numbers in women who received Megathiamine than those who received Placebo(10 vs 5), Oligohydramnios, Fetal Growth Restriction(FGR) and Hypertensive Diseasesof Pregnancy (HDsP) were not different in both groups.In Megathaimine grouppreterm births and LBW were more than placebo 55 (38.4Percentage) vs 44 (33.88Percentage), respectively in Megathaimine, placebo groups. Admissions to Neonatal Intensive Care Unit (NICU) were more is Megathaimine group comparedto Placebo (45 (0.9Percentage) vs 23 (4.6Percentage). Conclusion Present study revealedthat Megathiamine had no benefitto mother or baby. Excessof Thiamine lead to ill effects in mothers, babies