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Psychosine variants as antigens for natural killer T cells
- Source :
- Chemical Science. 8:2204-2208
- Publication Year :
- 2017
- Publisher :
- Royal Society of Chemistry (RSC), 2017.
-
Abstract
- Natural killer T (NKT) cells play a central role in the interface between innate and adaptive immunity, and alpha-galactosylceramide was recently shown to be an endogenous antigen for these cells. The source of alpha-galactosylceramide has not yet been determined; however, in vivo degradation of alpha-galactosylceramide involves generation of alpha-psychosine (alpha-galactosylsphingosine). Alpha-psychosine stimulates cytokine release from NKT cells and constitutes an endogenous antigen for these cells. Alpha-psychosine contains a single lipid chain, while most antigens for NKT cells have two lipid chains, and we have investigated if other glycolipids with one lipid chain, derived from know antigens for NKT cells, stimulate cytokine release from NKT cells. Only psychosine variants derived from the most potent NKT cell antigens cause stimulation, and this stimulation occurs in vitro as well as in vivo. Truncated forms of weak antigens for NKT cells are not stimulatory.
- Subjects :
- 0301 basic medicine
medicine.medical_treatment
Cell
CD1
hemic and immune systems
chemical and pharmacologic phenomena
General Chemistry
Biology
Acquired immune system
Natural killer T cell
In vitro
3. Good health
Cell biology
03 medical and health sciences
030104 developmental biology
medicine.anatomical_structure
Cytokine
Glycolipid
Antigen
medicine
Subjects
Details
- ISSN :
- 20416539 and 20416520
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Chemical Science
- Accession number :
- edsair.doi...........3c4fca7df3c4dc28849c5f60fc2e61ed