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Insulinsezernierende Zellen zur Therapie des Diabetes mellitus
- Source :
- Naturwissenschaften. 83:1-5
- Publication Year :
- 1996
- Publisher :
- Springer Science and Business Media LLC, 1996.
-
Abstract
- Even with intensive insulin therapy it is impossible to reach physiological blood glucose levels in insulin-dependent diabetes mellitus. Because of the high costs and technical problems involved in islet cell transplantation broad applicability of this therapy seems uncertain. An alternative approach is the development of molecular-engineered insulin-producing clonal cell lines. The main interest is in rodent insulinoma cell lines and neuroendocrine AtT-20ins cells. This paper reviews the current knowledge about glucose-stimulated insulin secretion and the problems that have to be solved before these cells can be used for therapy in diabetes mellitus.
- Subjects :
- medicine.medical_specialty
Islet cell transplantation
endocrine system diseases
business.industry
Insulin
medicine.medical_treatment
General Medicine
medicine.disease
Endocrinology
Cell culture
Diabetes mellitus
Internal medicine
Medicine
business
Insulin secretion
Insulinoma
Ecology, Evolution, Behavior and Systematics
Subjects
Details
- ISSN :
- 14321904 and 00281042
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- Naturwissenschaften
- Accession number :
- edsair.doi...........3b9424b7c576d537d20a1bf75f612e1a