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The first recurring chromosome translocation in hepatoblastoma: Der(4)t(1;4)(q12;q34)
- Source :
- Genes, Chromosomes and Cancer. 19:291-294
- Publication Year :
- 1997
- Publisher :
- Wiley, 1997.
-
Abstract
- We report four cases of hepatoblastoma with a derivative chromosome 4 from an unbalanced translocation between the long arms of chromosomes 1 and 4, an aberration reported only rarely in isolated cases of other types of neoplasms. The abnormality in three hepatoblastomas was der(4)t(1;4)(q12;q34), whereas the fourth case appeared to have a der(4)t(q25;q32). All had hyperdiploid tumor karyotypes; however, in the case with t(q25;q32), the der(4) was the only abnormality in the stemline. We speculate that the oncogenetic event in our cases may be the loss of a gene on distal 4q or their alteration by juxtaposition to 1q12 heterochromatin.
Details
- ISSN :
- 10982264 and 10452257
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Genes, Chromosomes and Cancer
- Accession number :
- edsair.doi...........3b3a2009ce514edb4afae18ebefbc823