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Synthesis of CF3-Substituted 1,6-Dihydropyridazines by Copper-Promoted Cascade Oxidation/Cyclization of Trifluoromethylated Homoallylic N-Acylhydrazines

Authors :
Danfeng Huang
Tianyu Yang
Ke-Hu Wang
Zhoubin Deng
Yulai Hu
Yingpeng Su
Pengfei Li
Source :
The Journal of Organic Chemistry. 85:12304-12314
Publication Year :
2020
Publisher :
American Chemical Society (ACS), 2020.

Abstract

A highly efficient strategy for the construction of CF3-substituted 1,6-dihydropyridazines has been developed by cascade oxidation/cyclization of trifluoromethylated N-acylhydrazines. The produced ...

Details

ISSN :
15206904 and 00223263
Volume :
85
Database :
OpenAIRE
Journal :
The Journal of Organic Chemistry
Accession number :
edsair.doi...........3b2755864fe758104c4e27861efdbe6f
Full Text :
https://doi.org/10.1021/acs.joc.0c01568