Back to Search
Start Over
Clinical studies on treatment of acute cerebral infarction with Xueshuantong injection
- Source :
- Chinese Journal of Integrative Medicine. 9:21-24
- Publication Year :
- 2003
- Publisher :
- Springer Science and Business Media LLC, 2003.
-
Abstract
- Objective: To observe the effect of Xueshuantong injection (XST, with its ingredient as Notoginseng saponin, on acute cerebral infarction (ACI) and on blood coagulation and fibrinolysis, so as to comprehensively analyse the mechanism of XST.Methods: Fifty ACI patients were randomly divided into 2 groups, and XST group (30 patients) was treated with XST, and the control group (20 patients) given low molecular dextrose, as well as low molecular heparin calcium. The course of treatment for both groups was 15 days. The changes of effective rate, score of neurologic impairment, tissuetype plasminogen activator (tPA), inhibitor of plasminogen activator (PAI), D-D dimmer, antithrombinIII (AT-III), and fibrinogen (Fbg) were all observed.Results: The total effective rate of XST group was 73.33%, that of the control group 65. 00%. After the therapy, plasma level of tPA, ratio of tPA/PAI, and AT-III content were increased obviously, while the plasma level of PAI and D-D dimmer were decreased significantly (all P 0.05).Conclusion: XST injection could be effective to ACI, the mechanism of which is probably related to improving the balance between plasminogen activator and its inhibitory factor, increasing the activity of fibrinolysin, inactivating thrombin, inhibiting platelet aggregation induced by thrombin, and decreasing blood coagulation.
- Subjects :
- medicine.medical_specialty
business.industry
medicine.medical_treatment
General Medicine
Pharmacology
Fibrinogen
Surgery
Thrombin
Complementary and alternative medicine
Coagulation
Acute cerebral infarction
Fibrinolysis
Medicine
Pharmacology (medical)
business
Fibrinolysin
Plasminogen activator
Heparin Calcium
medicine.drug
Subjects
Details
- ISSN :
- 19930402 and 16720415
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Chinese Journal of Integrative Medicine
- Accession number :
- edsair.doi...........3b1f9ccf4fba0e469247a786865890d5