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Polyurethanes in pharmacy — current state and perspectives of the development
- Source :
- Polimery. 59:689-698
- Publication Year :
- 2014
- Publisher :
- LUKASIEWICZ Research Network - Industrial Chemistry Research Institute, 2014.
-
Abstract
- The paper is a literature review concerning the preparation and biomedical properties of polyurethanes for pharmaceutical applications. The basic uses of polyurethanes in pharmacy comprise modern drug formulations (including therapeutical systems, carriers and conjugates). Clinical studies indicate that the application of polymer—drug conjugates has a beneficial effect on the therapy efficacy. The introduction of such conjugates into the body results in an increase in drug therapeutic index as an effect of increased drug availability in the affected areas,while at the same time reducing systemic exposure to the drug.Owing to the application of polyurethane conjugates, it is also possible to reduce the side effects and toxicity of drugs. It is expected that the studies on macromolecular drug conjugates (including polyurethanes) will stimulate the development of modern forms of drugs and broadly defined medicinal chemistry.
- Subjects :
- Drug
Polymers and Plastics
business.industry
General Chemical Engineering
Biomedical polymers
media_common.quotation_subject
Macromolecular drug
Drug availability
Pharmacy
Pharmacology
Drug formulations
Combinatorial chemistry
Therapeutic index
Materials Chemistry
Medicine
Therapy efficacy
business
media_common
Subjects
Details
- ISSN :
- 00322725
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Polimery
- Accession number :
- edsair.doi...........3b09ca168b0bbf9c491be14dffee7673