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Syntheses of [14C]-labeled 2-(3-chlorophenyloxy)-3-[3-(3-hydroxy) pyridin-4-yl propoxy]pyridine, a phosphodiesterase 4 inhibitor and its metabolites
- Source :
- Journal of Labelled Compounds and Radiopharmaceuticals. 57:477-479
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- We describe here the synthesis of [14C]-2-(3-chlorophenyloxy)-3-[3-(3-hydroxy)pyridin-4-yl propoxy]pyridine (1), a phosphodiesterase 4 inhibitor. [14C]-Labeled 1 was prepared in three steps from [14C]-2-bromopyridin-3-ol in an overall yield of 32%. Preparation of [14C]-labeled 2 and 3, two metabolites of 1, is also described. Copyright © 2014 John Wiley & Sons, Ltd.
Details
- ISSN :
- 03624803
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Journal of Labelled Compounds and Radiopharmaceuticals
- Accession number :
- edsair.doi...........3ac2ce8217117c426c3e6da72de00822