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Efficacy of tenofovir disoproxil fumarate therapy in Chinese chronic hepatitis B patients after multiple antiviral failures
- Source :
- Hepatology Research. 45:E43-E52
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- AIM In this prospective study, we aimed to evaluate the efficacy and safety of tenofovir disoproxil fumarate (TDF) in Chinese chronic hepatitis B (CHB) patients after multiple nucleoside/nucleotide analog (NA) treatment failures. METHODS A total of 115 Chinese CHB patients with suboptimal response to two or more NA treatments were included in this study. All patients were changed to TDF (300 mg/day, oral administration) antiviral treatment for at least 72 weeks. Hepatitis B virus (HBV) polymerase (P) gene mutation screening for each patient was performed. In addition, virological, biochemical responses and estimated glomerular filtration rate (eGFR) of each patient at weeks 12, 24, 48 and 72 of TDF treatment were evaluated. RESULTS Seventy-six out of 115 patients had drug-resistance mutations (R(+) ), including 27 with adefovir (ADV)-associated mutations (35.5%) and 49 with lamivudine (LMV)-associated mutations (64.5%). For all included patients, complete viral response (CVR) of HBV DNA (
- Subjects :
- Hepatitis B virus
medicine.medical_specialty
Hepatology
business.industry
Renal function
Lamivudine
Gene mutation
Pharmacology
Hepatitis B
medicine.disease_cause
medicine.disease
Gastroenterology
Infectious Diseases
Oral administration
Internal medicine
medicine
Adefovir
business
Prospective cohort study
medicine.drug
Subjects
Details
- ISSN :
- 13866346
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Hepatology Research
- Accession number :
- edsair.doi...........3a3e3106340e6770c641a2577ae174b8