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ChemInform Abstract: Isolation of 8′-Phosphate Ester Derivatives of Amicoumacins: Structure-Activity Relationship of Hydroxy Amino Acid Moiety
- Source :
- ChemInform. 39
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- Two new compounds, 8'-phospho derivatives of amicoumacins A and B, were isolated from the culture broth of a strain of Bacillus pumilus together with amicoumacins A and B. Their structures were elucidated on the basis of spectroscopic methods and alkaline phosphatase treatments. Comparison of the antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) of these compounds suggested that C-8' hydroxyl and C-12' amide group of amicoumacin A played a critical role for anti-MRSA activity.
- Subjects :
- chemistry.chemical_classification
biology
Bacillus pumilus
Stereochemistry
General Medicine
biology.organism_classification
Phosphate
medicine.disease_cause
Amino acid
chemistry.chemical_compound
chemistry
Staphylococcus aureus
Amide
medicine
Moiety
Structure–activity relationship
Alkaline phosphatase
Subjects
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........39b7bda7c4c99aaa6c22dc8d6e0bae9a