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Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues

Authors :
Graeme I. Bell
T. B. Shows
Yao Shan Fan
Hirofumi Fukumoto
Toshiaki Kayano
R. L. Eddy
M. G. Byers
Source :
Journal of Biological Chemistry. 263:15245-15248
Publication Year :
1988
Publisher :
Elsevier BV, 1988.

Abstract

Complementary DNA clones encoding a glucose transporter-like protein have been isolated from a human fetal skeletal muscle cDNA library. The 496-amino acid fetal muscle glucose transporter-like protein has 64.4 and 51.6% identity with the previously described human erythrocyte/HepG2 and liver glucose transporter sequences, respectively. RNA blotting studies indicate that transcripts encoding this glucose transporter-like protein are present in most tissues, although their relative abundance varies. The gene encoding this protein has been localized to human chromosome 12p13.3. The identification and characterization of a third human glucose transporter-related protein suggests that there is a family of proteins having similar sequences and structures which are involved in nutrient transport by mammalian cells.

Details

ISSN :
00219258
Volume :
263
Database :
OpenAIRE
Journal :
Journal of Biological Chemistry
Accession number :
edsair.doi...........398f732725ff1753beecd5e16a730330
Full Text :
https://doi.org/10.1016/s0021-9258(19)37577-5