Genetic differences in reactivity of lymphoid tissue during regeneration of the liver in different strains of mice

Transplantation of lymphocytes from partially hepatectomized CBA and C57BL mice, together with sheep's red cells, into lethally irradiated syngeneic mice showed that the CBA mice acquired the ability to increase the number of antibody-forming cells much sooner after the operation (4 h) than C57BL mice (17 h). Transplantation of the lymphocytes in a semisyngeneic system led, as a result of the graft versus host reaction (GVHR), to a decrease in the number of antibody-forming cells during subsequent immunization of the recipients with sheep's red cells. The GVHR was less severe in the hepatectomized mice than in the controls. These changes also appeared sooner after the operation in CBA mice than in C57BL mice.