Piroxicam ex vivo release kinetics from zein/pectin delivery systems

Piroxicam ex vivo release kinetics from zein/pectin drug delivery systems were studied using rat cecum. The piroxicam release kinetic parameters were calculated using a first-order equation and the Peppas equation. The results indicated that diffusion of the therapeutic agent was the rate-limiting step in piroxicam release from the hydrogel microspheres. The created therapeutic drug forms based on biodegradable polymers were an alternative to the peroral administration of most drugs with limited bioavailability.