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Physicochemical, structural and biological evaluation of Cybersan (trigalactomargarate), a new glycolipid biosurfactant produced by a marine yeast, Cyberlindnera saturnus strain SBPN-27

Physicochemical, structural and biological evaluation of Cybersan (trigalactomargarate), a new glycolipid biosurfactant produced by a marine yeast, Cyberlindnera saturnus strain SBPN-27

Authors :
C. Ganesh Kumar
S. Jayalakshmi
Shanmugasundaram Senthil Balan
Source :
Process Biochemistry. 80:171-180
Publication Year :
2019
Publisher :
Elsevier BV, 2019.

Abstract

Recent attention on marine microbes has gained a renewed interest on natural product-based drug discovery with functional potential. Nevertheless, marine yeasts were less explored from a bioindustrial and biomedical perspective, especially on biosurfactants regardless no novel structures were identified till date. Considering these facts, this study screened biosurfactants from marine yeasts having broad spectrum industrial significance with the basic tensioactive properties, emulsification and non-hemolytic activities. Among the 136 strains isolated from three different stations of Tamil Nadu, India, Cyberlindnera saturnus SBPN-27 exhibited promising features. The biosurfactant from this marine yeast was purified and structurally characterized as Gal-Gal-Gal-Heptadecanoic acid (named as Cybersan) based on different spectral analysis. Further, Cybersan revealed surface tension of 28 mN m−1 at critical micelle concentration of 30 mg L−1 and stability over a broad pH and temperature conditions. Cybersan showed appreciable growth inhibition toward the clinical bacterial pathogens and revealed no considerable cytotoxicity against the mammalian 3T3 fibroblast cells suggesting its biocompatible nature. This is the first report on a new biosurfactant from a marine yeast having diverse functional properties and evidenced as promising candidate for mammalian safe antimicrobial therapy and other biomedical applications.

Details

ISSN :
13595113
Volume :
80
Database :
OpenAIRE
Journal :
Process Biochemistry
Accession number :
edsair.doi...........38ba7200be922f8f8bbfdeb59963f864
Full Text :
https://doi.org/10.1016/j.procbio.2019.02.005