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Larger Interventricular Conduction Time Enhances Mechanical Response to Resynchronization Therapy

Authors :
Luigi Padeletti
Paolo Pieragnoli
Margherita Padeletti
Vincenzo Lionetti
Sergio Valsecchi
Laura Perrotta
Gino Grifoni
Ilaria Ricceri
Alessandro P. Perini
Giuseppe Ricciardi
Source :
Pacing and Clinical Electrophysiology. 36:416-423
Publication Year :
2013
Publisher :
Wiley, 2013.

Abstract

Background Previous studies have reported that the left ventricular (LV) pacing site is a major determinant of the hemodynamic response to cardiac resynchronization therapy (CRT). However, lead positioning in a lateral or posterolateral cardiac vein may not be optimal for every patient. The objective of this study was to assess the relationship between the right ventricular (RV)-to-LV conduction time and the systolic function during CRT on the basis of changes to LV pressure-volume loops. Methods Left ventricular pressure and volume data were determined using a conductance catheter during CRT device implantation in 10 patients. Four endocardial LV sites were systematically assessed at four atrioventricular delays. The RV-to-LV conduction time was measured as the time interval between spontaneous peak R waves, recorded through the RV lead and the LV catheter. Results The optimal pacing site varied among patients. However, the pacing site associated with the maximum RV-to-LV conduction time resulted in a stroke volume improvement comparable to the pacing site identified through individual hemodynamic optimization (41 ± 17 mL vs 44 ± 18 mL, P = 0.266). Moreover, the RV-to-LV conduction time recorded at each endocardial pacing site correlated positively with the increase in stroke volume (r = 0.537; P < 0.001), stroke work (r = 0.642; P < 0.001), and the pressure-derivative maximum (r = 0.646; P < 0.001) obtained with CRT. Conclusions An optimal acute response to CRT can be obtained by positioning the LV lead at the site associated with the maximum RV-to-LV conduction time. A significant correlation appears to exist between RV-to-LV conduction time and the improvement in systolic function with CRT.

Details

ISSN :
01478389
Volume :
36
Database :
OpenAIRE
Journal :
Pacing and Clinical Electrophysiology
Accession number :
edsair.doi...........386c967403da16d3ced43ab4faafb058