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Decapping the message: a beginning or an end

Authors :
Megerditch Kiledjian
H. Liu
Source :
Biochemical Society Transactions. 34:35-38
Publication Year :
2006
Publisher :
Portland Press Ltd., 2006.

Abstract

Removal of the mRNA 5′ cap is an important step in the regulation of mRNA stability. mRNAs are degraded by at least two distinct exonucleolytic decay pathways, one from the 5′ end, and the second from the 3′ end. Two major cellular decapping enzymes have been identified, and each primarily functions in one of the two decay pathways. The Dcp2 decapping enzyme utilizes capped mRNA as substrate and hydrolyses the cap to release m7GDP (N7-methyl GDP), while a scavenger decapping enzyme, DcpS, utilizes cap dinucleotides or capped oligonucleotides as substrate and releases m7GMP (N7-methyl GMP). In this review, we will highlight the function of different decapping enzymes and their role in mRNA turnover.

Details

ISSN :
14708752 and 03005127
Volume :
34
Database :
OpenAIRE
Journal :
Biochemical Society Transactions
Accession number :
edsair.doi...........37fb5a8e438b5e498a365b8b86af1339
Full Text :
https://doi.org/10.1042/bst0340035