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Alterations in regional shape on ipsilateral and contralateral cortex contrast in children with unilateral cerebral palsy and are predictive of multiple outcomes
- Source :
- Human Brain Mapping. 37:3588-3603
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Congenital brain lesions result in a wide range of cerebral tissue alterations observed in children with cerebral palsy (CP) that are associated with a range of functional impairments. The relationship between injury severity and functional outcomes, however, remains poorly understood. This research investigates the differences in cortical shape between children with congenital brain lesions and typically developing children (TDC) and investigates the correlations between cortical shape and functional outcome in a large cohort of patients diagnosed with unilateral CP. Using 139 structural magnetic resonance images, including 95 patients with clinically diagnosed CP and 44 TDC, cortical segmentations were obtained using a modified expectation maximization algorithm. Three shape characteristics (cortical thickness, curvature, and sulcal depth) were computed within a number of cortical regions. Significant differences in these shape measures compared to the TDC were observed on both the injured hemisphere of children with CP (P
- Subjects :
- medicine.medical_specialty
Neurology
Brain damage
Audiology
050105 experimental psychology
Cerebral palsy
03 medical and health sciences
0302 clinical medicine
Cortex (anatomy)
Neuroplasticity
medicine
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
05 social sciences
Magnetic resonance imaging
Cognition
medicine.disease
medicine.anatomical_structure
Brain size
Neurology (clinical)
Radiology
Anatomy
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10659471
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Human Brain Mapping
- Accession number :
- edsair.doi...........37b29db2b99e5b1588f0bd03fb646368