Resting State Functional Magnetic Resonance Study Based on Amplitude of Low-Frequency Fluctuation in Patients with Acute Angle-Closure Glaucoma

Objective: To investigate the altered brain spontaneous activity in acute angle-closure glaucoma (AACG) using resting-state amplitude of low-frequency fluctuation (ALFF).Methods: Eighteen AACG patients and eighteen age, gender-matched healthy controls (HC) were included in the rs-fMRI scans. Two sample t tests were performed to observe the ALFF changes between AACG and HC. The correlations between ALFF values and the ophthalmologic measurements were analyzed.Results： Compared with HC，AACG patients showed decreased ALFF in the right lingual gyrus, right supra marginal gyrus , left precuneus，left medial superior frontal gyrus, left inferior parietal gyrus , left middle frontal gyrus. Meanwhile AACG patients showed increased ALFF in the right lobule crus2 of cerebellar hemisphere , left V1, right cuneus. In this study, no correlation between brain regions with abnormal ALFF value and intraocular pressure was found.Conclusion: AACG patients have abnormal brain spontaneous activity in the visual, sensual, motional and emotional areas, which provides a new insight into the neuropathological mechanism and treatment of AACG.