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Deletion/Insertion Polymorphism of the Angiotensin-Converting Enzyme Gene and White Matter Hyperintensities in Dementia: A Pilot Study
- Source :
- Journal of the American Geriatrics Society. 54:1395-1400
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- OBJECTIVES: To examine the association between the angiotensin-converting enzyme (ACE) deletion/insertion (D/I) polymorphism and white matter hyperintensities (WMHs) in patients with dementia. DESIGN: Observational pilot study with adjustment for potential confounders using analysis of covariance. SETTING: Secondary care old-age psychiatry services in greater Manchester, United Kingdom. PARTICIPANTS: Ninety-seven patients with dementia: 49 with Alzheimer's disease (AD, National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association criteria) and 48 with vascular dementia (VaD, National Institute of Neurological Disorders and Stroke/Association Internationale pour la Recherche et l'Enseignement en Neurosciences criteria). MEASUREMENTS: The ACE D/I polymorphism, WMHs (deep WMHs (DWMHs) and periventricular hyperintensities (PVHs)) on T2-weighted magnetic resonance imaging, and potential cardiovascular confounders. RESULTS: The D/D polymorphism of the ACE genotype was associated with severity of DWMH (P = .005) but not PVH (P = .34), corrected for age, cardiovascular risk factors, and type of dementia. Post hoc analyses were limited by statistical power but suggested an interaction with the apolipoprotein E epsilon4 allele. CONCLUSION: The results support previous observations that genetic factors influence the development of WMHs in dementia. The involvement of the ACE D/I polymorphism in the pathogenesis of DWMHs in dementia (AD and VaD), by a mechanism that is independent of its association with cardiovascular risk factors, should be confirmed in a large population-based sample.
- Subjects :
- Apolipoprotein E
Gerontology
medicine.medical_specialty
biology
business.industry
Confounding
Angiotensin-converting enzyme
medicine.disease
Hyperintensity
Central nervous system disease
Degenerative disease
Internal medicine
medicine
biology.protein
Dementia
Geriatrics and Gerontology
Vascular dementia
business
Subjects
Details
- ISSN :
- 15325415 and 00028614
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Journal of the American Geriatrics Society
- Accession number :
- edsair.doi...........377e9160967542c6fe9e6bdeecba870d