ChemInform Abstract: Reaction of Achiral Titanium Z-Enolates with Chiral α-Silyloxy Aldehydes

Aldol reactions between the putative Z-enolate derived from 2-methyl-3-pentanone and several chiral α-tert-butyldiphenylsilyloxy aldehydes have been studied. The stereochemical outcome suggests that stereoelectronic effects play a dominant role in these reactions and the results can be accommodated by the Felkin model, with gauche pentane interactions being less important.