Application of CR-39 for alpha-autoradiography and in vivo detection of 10B accumulations in tumor bearing mice

It is required to achieve an accurate measurement of 10 B distributions and concentrations in the tumor cells for boron neutron capture therapy (BNCT). We employed a technique of neutron capture autoradiography (NCAR) of the whole body samples of tumor bearing mice using CR-39 plastic track detectors to the measurements of 10 B accumulations in mice. In order to confirm the validity of the NCAR measurements, the differential REL spectrum for the neutron-induced particles emitted from the standard filter paper sheets was compared with that for 10 B-compound solution. Differential REL spectrum for protons originated from the biogenically abundant nuclides through 14 N (n, p) 14 C and 1 H (n, n′) 1 H reactions was measured in vivo using a small piece of CR-39 inserted into the tumor of mouse.