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Quantification of carcinoembryonic antigen-like activities in normal human gastrointestinal secretions
- Source :
- Cancer. 36:2346-2350
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- The secretion of carcinoembryonic antigen-like (CEA-like) material into the gastrointestinal tract of 28 fasting normal men was quantified by using intestinal perfusion techniques. CEA-like material was recovered from all levels of the gastrointestinal tract. The highest secretory rate was in the colon (mean +/- SE, 2.41 +/- 2.0 mug/minute per colon), followed by pancreatobiliary secretion and pancreatic secretion. The secretory rate from the stomach, duodenum, jejunum, and ileum was less than 20 ng/minute. After perchloric acid extraction, the CEA-like material from the colon had the same chromatographic and radioimmunologic properties as [125I] CEA. These data suggest that the CEA-like material is normally secreted into the gastrointestinal tract and particularly into the colon.
- Subjects :
- Cancer Research
Gastrointestinal tract
medicine.medical_specialty
endocrine system diseases
biology
business.industry
Secretory Rate
Stomach
Ileum
Gastroenterology
digestive system diseases
Jejunum
medicine.anatomical_structure
Carcinoembryonic antigen
Oncology
Internal medicine
medicine
biology.protein
Duodenum
Secretion
business
neoplasms
Subjects
Details
- ISSN :
- 10970142 and 0008543X
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Cancer
- Accession number :
- edsair.doi...........363f2cf923b42b4236a78582bc7bdcd5