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Concurrent juvenile myelomonocytic leukemia and T-lymphoblastic lymphoma with a shared missense mutation inNRAS
- Source :
- Pediatric Blood & Cancer. 61:946-948
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Single cases of B- and T-lymphoblastic leukemia/lymphoma occurring after remission of JMML, and JMML occurring after remission of B-lymphoblastic leukemia have been reported in the literature. We present a unique case of a child with concurrent JMML and T-lymphoblastic lymphoma in which an identical missense mutation in NRAS was found in both the neoplastic JMML and T-LBL cells. JMML has been considered a stem cell disorder, and our case provides additional molecular evidence for a stem cell lesion underlying the two different disease phenotypes.
- Subjects :
- Neuroblastoma RAS viral oncogene homolog
Juvenile myelomonocytic leukemia
business.industry
Lymphoblastic lymphoma
hemic and immune systems
Hematology
medicine.disease
Lymphoma
Lesion
Leukemia
Oncology
hemic and lymphatic diseases
Pediatrics, Perinatology and Child Health
Immunology
medicine
Missense mutation
medicine.symptom
Stem cell
business
Subjects
Details
- ISSN :
- 15455009
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Pediatric Blood & Cancer
- Accession number :
- edsair.doi...........3601a37aae536c1fa2f73ad1aca8a791