Back to Search Start Over

c-MAF dependent perivascular macrophages regulate diet induced metabolic syndrome

Authors :
Queiroz
Kroehling
Moura Silva
Lafaille
Matheis
Littman
Bozza
Mucida
Lu Yang
Kitoko
Ren-Fielding
Publication Year :
2021
Publisher :
Cold Spring Harbor Laboratory, 2021.

Abstract

SUMMARYMacrophages are an essential part of tissue development and physiology. Perivascular macrophages have been described in tissues and appear to play a role in development and disease processes, although it remains unclear what are the key features of these cells. Here, we identify a subpopulation of perivascular macrophages in several organs, characterized by their dependence on the transcription factor c-MAF, displaying non-conventional macrophage markers including LYVE1, Folate receptor 2 and CD38. Conditional deletion of c-MAF in macrophage lineages caused ablation of perivascular macrophages in the brain and altered muscularis macrophages program in the intestine. In the white adipose tissue (WAT), c-MAF deficient perivascular macrophages displayed an altered gene expression profile, which was linked to an increased vascular branching into the tissue. Upon feeding on high fat diet (HFD), mice with c-MAF deficient macrophages showed improved metabolic parameters compared to wild-type mice, including less weight gain, greater glucose tolerance and reduced inflammatory cell profile in WAT. These results define c-MAF as a central regulator of perivascular macrophages cell identity and transcriptional program in vivo and reveal a novel role for this tissue resident macrophage population in the regulation of metabolic syndrome.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........35f54e559c23e6f2815288259a89248a
Full Text :
https://doi.org/10.1101/2021.02.07.430147