Back to Search
Start Over
Test-retest reproducibility of extrastriatal binding with 123 I-FP-CIT SPECT in healthy male subjects
- Source :
- Psychiatry Research: Neuroimaging. 258:10-15
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- 123I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123I-FP-CIT) is used to assess striatal dopamine transporter (DAT) expression, but it can also quantify extrastriatal serotonin transporter (SERT) expressions. While FP-CIT uptake in extrastriatal regions has been quantified, no information exists on the reproducibility of the 123I-FP-CIT specific uptake ratio (SUR) in extrastriatal regions. We investigated test-retest reproducibility of 123I-FP-CIT binding in the striatum, the midbrain, and cortical regions in eight healthy male subjects. All subjects underwent two 123I-FP-CIT SPECT scans, and SUR was calculated using the cerebellum as the reference. We found good test-retest reproducibility of 123I-FP-CIT SUR in the midbrain, and in the lateral frontal/temporal cortex and combined cortical regions. The overall variability and intraclass correlation of SUR were, respectively, 4.9-7.8% and 0.90-0.96 in striatal regions, 8.6% and 0.79 in the midbrain, and 3.6-9.1% and 0.84-0.95 in the lateral frontal/temporal cortex and combined cortical regions. Our results provide evidence that 123I-FP-CIT SPECT is a valid technique for analyzing striatal DAT, as well as extrastriatal SERT in areas such as the SERT-enriched midbrain. In addition, our data suggest that 123I-FP-CIT could be used for analyzing SERT in regions with relatively low SERT expression (e.g., temporal or frontal cortices).
- Subjects :
- Temporal cortex
Reproducibility
Cerebellum
biology
Intraclass correlation
business.industry
Neuroscience (miscellaneous)
Striatum
030218 nuclear medicine & medical imaging
Midbrain
03 medical and health sciences
Psychiatry and Mental health
0302 clinical medicine
medicine.anatomical_structure
Cortex (anatomy)
biology.protein
medicine
Radiology, Nuclear Medicine and imaging
Psychology
Nuclear medicine
business
Neuroscience
030217 neurology & neurosurgery
Serotonin transporter
Subjects
Details
- ISSN :
- 09254927
- Volume :
- 258
- Database :
- OpenAIRE
- Journal :
- Psychiatry Research: Neuroimaging
- Accession number :
- edsair.doi...........35c72a06ab6d5ced4b9f61bf9588aca4
- Full Text :
- https://doi.org/10.1016/j.pscychresns.2016.10.007